CODDHI 2011- FOCO Perspectivas em DM – VitD: Mitos e Verdades

Muitas dúvidas em um campo ainda desconhecido para a ciência médica foram discutidas pelo Dr Sérgio Atala Dib (UNIFESP). Dr Paulo Lacativa e Dra Rosane Kupfer foram os debatedores.
O mercado Americano de Vitamina D movimenta atualmente 425 milhoes de dólares. Um valor alto, principalmente quando avaliamos as cifras de 2001 – 40 milhoes e 2005 – 50 milhoes.
Este aumento do interesse, se origina na descoberta de receptores de vitamina D na celulas pancreáticas e sistema imune. A vit D tem ação supressora em TH1 e TH2 e ação estimuladora de linfócitos t reguladores.
Dr. Sérgio Dib definiu alguns pontos sobre a vitamina D, como verdades sobre a ação Anti- Inflamatoria e Imunomoduladora desta vitamina e mitos como a deficiencia aumentar a mortalidade por IAM e AVC.
Surgiram dúvidas no que tange a suplementação com a Vitamina D como forma de proteção para o DM1 e DM 2, onde demonstrou estudos que não sustentavam esta hipótese.
Atualmente os valores de referencia são 30-50 (ng/mL) de 25 (OH)D3.
Para avaliação da Vitamina D, a 25(OH)D3 deve ser mensurada devido a sua meia vida de 3 semanas. A forma ativa 1,25(OH)D3 possui meia vida de 4 – 6 h, o que dificulta sua utilização.
Foi ressaltado que em pacientes obesos os valores de reposição são 2x maiores que em indivíduos não obesos.

Esta entrada foi publicada em CODDHi 2011. Adicione o link permanenteaos seus favoritos.

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