CODDHI 2011: Apneia do sono e doenças cardiometabólicas

Apnéia obstrutiva do sono (AOS) e Síndrome de apnéia obstrutiva do sono (SAOS)

Esse foi mais um tema discutido no CODDHI 2011 pelos doutores Antonio Felipe Sanjuliani e Mário Frischque despertou o nosso interesse .
A AOS é uma patologia mais prevalente em homens, em maiores de 65 anos, em pacientes com o aumento do depósito de gordura faríngea, ou com comprimento curto do palato mole e alterações estruturais das VAS (vias aéreas superiores). A obesidade, principalmente a central, é um importante fator de risco pelos efeitos mecânicos sobre as VAS e os pulmões.
Um fato interessante é que resistência insulínica nas pacientes com SOP (síndrome dos ovários policísticos ) pode ser um importante preditor de SAOS. Podemos suspeitar da SAOS em pacientes hipertensos refratários em uso de 3 drogas (sendo uma delas o diurético), DM2 de difícil controle, pacientes com FA, ICC descompensada dentre outras patologias.
A SAOS ocorre quando além da apnéia ocorre prejuízos para o paciente como sonolência, diminuição da qualidade de vida, diminuição da concentração, da memória e da libido , irritabilidade ou cefaléia matinal . Um importante sintoma de apnéia são os roncos e engasgos que são queixas referidas pelos parceiros.
O que torna a SAOS tão importante? Os grandes “vilões” são os despertares noturnos. Ocorre uma hipóxia intermitente e fragmentações do sono ao despertar => Aumenta a descarga simpática adrenérgica, aumenta o estresse oxidativo e as espécies reativas de oxigênio,há aumento do NFkß o que leva ao aumento de moléculas de adesão e de ácidos graxos livres além de diminuir as adiponectinas.
1. Obesidade e SAOS: a obesidade é um fator de risco importante, porém, pode também ser uma conseqüência da SAOS por um mecanismo hipotalâmico devido à diminuição da leptina e o aumento da grelina.
2. HAS e SAOS: a SAOS altera o controle pressórico, o paciente perde o descenso noturno da pressão arterial.
3. Arritmias cardíacas, coronariopatia e SAOS: algumas arritmias são mais incidentes nos pacientes com SAOS ( taquiarritmias , BAV 2 grau, ESV, FA) , além do mais há um aumento do processo aterosclerótico , descargas simpáticas e hipoxemias noturnas que se associadas a outros fatores de risco aumentam o risco de infarto agudo do miocárdio.

O screening é feito através de alguns questionários: Questionário Clínico de Berlim, Questionário de Epworth.
O diagnóstico é feito pela polissonografia: quando temos maior ou igual 5 episódios/hora + 1 sintoma ( roncos e/ou apnéia, fadiga, sonolência, outros) ou mais que 15 episódios/hora.
O tratamento consiste no controle dos fatores de risco, principalmente perda de peso, exercícios físicos, evitar posição supina, correção dos fatores anatômicos e CPAP.
Fatores de piora da SAOS também devem ser evitados como o uso de benzodiazepínico e a ingesta de álcool.
Algumas considerações são importantes :
• SAOS aumenta o risco de doença cardiovascular quando há outros fatores de risco.
• O paciente com AOS mas sem SAOS não tem risco cardiovascular aumentado.
• Nem todo paciente que ronca tem SAOS
• Quando houver suspeita da doença, procure um especialista.

Esta entrada foi publicada em CODDHi 2011. Adicione o link permanenteaos seus favoritos.

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