Metformina: Muito Além do Glucocentrismo

“ Peripheral insulin-sensitizer drug metforin ameliorates neuronal insulin resistance and Alzheimer´s-like changes” – Neuropharmacology 60 (2011) 910-920

O artigo sobre o estudo experimental em células de neuroblastoma demonstrou a existência de resistência insulínica neuronal e os efeitos da metformina.

O estudo foi dividido em 3 partes avaliando a resposta dos mecanismos intracelulares e fisiopatológicos  à ação da metformina sobre:

1- Vias de Sinalização da insulina

2- Mecanismo da Fisiopatologia da Doença de Alzheimer: Proteínas Tau e ERK

3- Atividade da Acetilcolinesterase

Foi demonstrado que  a  metformina diminuiu a resistência insulínica neuronal e reverteu alguns dos processos fisiopatológicos da doença de Alzheimer reduzindo inclusive a atividade da acetilcolinesterase.

Este estudo, é um passo inicial para estudarmos medicações com melhor custo beneficio para o tratamento do Alzheimer. Será necessário sua replicação em seres humanos com avaliação da capacidade cognitiva para ratificarmos esta possível atividade da metformina.

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